Chitosan Fiber Medical Hygiene Application Seminar Report Highlights

Development and application of medical textile materials

Yu Jianyong, Academician of the Chinese Academy of Engineering

Medical textile materials are textile materials based on fiber, textile technology for manufacturing methods, medical applications, for diagnostic, therapeutic, repair, replacement, and health care and protection. At present, the new technologies in the world mainly focus on the fiber scale and the structural controllability of pores, such as the application of electrostatic nanofibers, the development of functional nonwoven materials for medical and health care, and the different fields of fiber properties. different. Medical textiles have many advantages in human medical treatment, such as various repair patches, surgical sutures, artificial blood vessels, etc., which have extremely high added value, but many high-end medical textiles in China are mainly dependent on the future. China's medical and sanitary textile industry should accelerate the development of new medical textile material fiber raw material system, break through the key technologies of high-end medical textile material processing and equipment, strengthen the construction of medical textile material testing and evaluation system, optimize and upgrade the medical textile material industry system, optimize and upgrade medical products. The textile material industry system will accelerate the establishment of high, medium and low-end complete medical textile material product systems, strengthen the frontier research of medical textile materials, enhance the independent innovation capability of high-end medical textile materials in China, accelerate the formation of industrial clusters , and promote the industrialization of new results. To strengthen the construction of talents in the field of biomedical textile materials, guided by market demand, to make China's medical products more widely used and create greater social and economic value.

Nature and comfort from the ocean - Haysmore Corporate Development and Brand Introduction

Hu Guangmin, Chairman of Hays Moore Biotechnology Co., Ltd.

Biomedical materials are high-growth industries. In 2015, the global medical device market exceeded US$300 billion, and medicines reached US$600 billion, reaching 1:2. The future ratio will reach 1:1. The annual growth rate of biomedical materials in China is over 20%, but the domestic market share is less than 10%, and the development space is quite huge. The driving factors for the development of biomedical materials are mainly the improvement of medical demand, the indispensability of human tissue and organ repair, the development of new technologies and the highest added value of materials technology.

According to EvaluateMedTech's statistics, the global medical device market will reach $477.5 billion in 2020. According to conservative estimates, in the flexible materials such as implantable hemostatic materials, in vitro medical dressings, sutures, artificial skin, and enamel patches, chitosan materials can not only replace existing products, but also develop more excellent performance. The new and differentiated series of new products , the medical industry space can reach more than 100 billion yuan. In 2015, the Ministry of Industry and Information Technology issued a list of 13 key cultivation projects, “Industrial Application of Pure Chitosan Fiber”, among which the chitosan fiber and application implementation plan for thousands of tons of medical and health care were supported by the transformation and upgrading of the Ministry of Industry and Information Technology. The annual production of 2,000 tons of pure chitosan fiber industrialization project was supported by the Development and Reform Commission.

Hais Moore is a transformation and upgrading of traditional textile enterprises. In the past ten years, from scratch to small, it has grown and developed. Looking back on the decade, the company explored the reverse of market demand and promoted and promoted interactive development. The paper-making model is recognized by the society and the market. In the future, the company will continue to strengthen the cooperation of industry, academia and research, and cooperate in product development and application of products to make the potential value of chitosan fiber more fully utilized.

Functional Mechanism and Product Development of Chitosan Fiber

Haisi Moore Biotechnology Co., Ltd. Chief Engineer Zhou Jiacun

Chitosan is a product of chitin deacetylation. In general, the removal of N-acetyl by more than 55% is called chitosan. Chitin is another important polysaccharide that is second only to cellulose. It is widely found in the carapace of fungi and plant cell walls, shrimps, crabs and other animals. Chitosan fiber is the only positively charged dietary fiber found in nature. It has excellent biocompatibility, broad spectrum bacteriostasis, biosafety, degradability, natural ecology, and human pro And, can be widely used in medical and aerospace and other fields, and has a broad market prospect.

Today, Haysmore has built the world's first 2000 tons of chitosan fiber hot air non-woven fabric production line and a four-line acupuncture and spunlace compound production line to build a non-woven fabric based on pure chitosan fiber. Technology System. Based on the characteristics of chitosan fiber itself, the company's aerospace chitosan fiber special cloth jointly developed by the company and China Aerospace Science and Technology Group can be used for cabin interior materials and soft water tank outer bags, packages and other equipment. Antibacterial, anti-mildew, anti-static, high-temperature degassing and non-toxic functions have passed the national military standard certification, making the company a qualified supplier of aerospace materials. Utilizing the functionality of chitosan fiber, the company cooperated with Taiwan BenQ to develop medical products such as applicator, hemostatic cotton, bandages, etc., to achieve 3 minutes of extrusion and hemostasis, and passed the EU CE certification, successfully used for emergency medical services, military medical , field rescue and other fields. The company's design and development of online high-speed addition of polymer "ultra-thin" sanitary napkins is only 2mm thick, water absorption rate of 50 times, 1200 tablets per minute, automatic feeding, automatic detection and rejection of waste products, automatic inkjet products with traceability, It is the world's first full-automatic sanitary napkin production line.

In general, through the use of marine waste, the company has opened up the industrial chain of raw materials extracted to the end products, realized the serial production of chitosan fibers, studied the functional mechanism of quick-acting pure chitosan fibers, and developed a health-oriented industry. The basic functional materials and products meet the requirements of biomedical and health and sanitation applications; break through a number of key technologies, international and domestic patents, and control of key links in the entire industry chain, reaching the leading position in technology and the world in equipment, The largest capacity in the world, consolidating and enhancing the international leading position of chitosan fibers and products.

Chitosan modification and assembly research and development and its functional application

Professor of Wuhan University, Du Yumin, Chairman of the Chitin Professional Committee of the Chinese Chemical Society

Chitosan is a natural macromolecule widely distributed in nature. It includes chitin and chitosan, and is defined by the acetyl content in its binary structure. By regulating chitosan-based structural factors, various kinds can be realized. Functional application. The physical properties and biological properties of chitosan can realize the high quality and functionalization of daily chemical products, and have been valued and developed by many industries in the world. Taking chitosan and chitosan as examples, they are widely used in biotechnology, medicine, food, cosmetics, chemical, light industry, environmental protection , agriculture, biomedical materials, etc., such as chitosan quaternary ammonium salt and The inorganic rectorite is hybridized, and its antibacterial property can be greatly improved. The nanofiber obtained by the chitosan can be used for reinforcing plastics and rubber, and the effect is very good.

The study found that the use of biosynthesis technology can promote the new development of the chitin industry: such as the production of chitosan by chitosan and chitinase deacetylation by microbial fermentation waste slag enzymatic method; chitosan synthesis by microbial fermentation Glucosamine, N-acetylglucosamine; Saccharomyces cerevisiae transformation to efficiently synthesize astaxanthin. Advantages of microbial fermentation engineering: many types of metabolites, wide sources of raw materials, low energy consumption, high economic benefits, and less environmental pollution.

Nowadays, new technologies for biomass materials are emerging, and low-concentration NaOH/urea aqueous solution dissolves chitin. This method provides a new way for chitin to prepare a series of functional materials (biomedical materials, photovoltaic energy storage materials and functional catalytic materials). The protein in the chitin is converted into a proteolytic peptide-metal complex, which has the effect of removing heavy metals (especially Cd) from the mussels and the crayfish. In addition, it also has the effect of inhibiting ACE and lowering blood pressure. These technologies will make the chitin industry move toward “deepening” processing and overall utilization.

Haysmore's chitosan fiber industry is a differentiated development path for the chitosan industry, and it is a broader and high-end application field for chitosan. The company is advised to move toward the new pharmaceutical industry and gain greater value in high value-added fields such as medical dressings, nerve conduits, tissue engineering scaffolds, gene carriers, and artificial skin.

Structural design, preparation and application of biomedical materials

Director of the Engineering Research Center for textile industry with Donghua University Chen Nanliang

There are many classifications of textile structures and processes. Among them, the machine (snake) fabric is characterized by warp and weft interlacing. The basic unit is the intersection point (organization point) between the warp and weft yarns. Its characteristics are compact / high-density, thin, stiff, suitable for the development of medical products, such as artificial blood vessels for intracavitary isolation, small-caliber artificial blood vessels, protective clothing, surgical towels and so on.

The braid is a set of yarns extending in the direction in which the fabric is formed, and all of the yarns are offset from each other by a certain angle. Classification of two-dimensional weaving, three-dimensional weaving, etc., the characteristics are mesh structure, machine, manual production, suitable for the development of medical products, such as sutures, artificial nerve catheters, endovascular stents.

Human peripheral nerve regeneration catheter is a hot spot of current research. It is a tubular body with a cavity that promotes nerve regeneration, replaces autologous nerve transplantation and functional recovery, and is commonly used for repair of peripheral nerve injury, suture closure, autologous nerve transplantation, allogeneic nerve transplantation, nerve transfer, and catheter connection. Wait.

The performance of nerve conduits is: good biocompatibility and histocompatibility, suitable biodegradability, the required three-dimensional space for nerve recovery, the size and length of the two ends suitable for connecting the injured nerve, It ensures the nutrient supply required for nerve repair, has certain compressive performance and maintains good blood supply, protects axons from regeneration and avoids infestation of scar tissue, and has appropriate pore size and porosity.

At present, the usual nerve conduit materials are PGA - the degradation rate is fast, especially the mechanical strength decays fast; PLA - high intensity, slow degradation rate, poor cell affinity; PGLA - both of the two polymeric components Advantages, the group distribution ratio can be changed, and the degradation cycle can be adjusted. The degradation cycle of PGLA (90:10) coincides with the nerve regeneration cycle (about 3 months), but its solubility is poor. In this regard, the coated nerve conduit material stands out. Because of its good solubility, easy material extraction and good film-forming properties, the chitosan has excellent performance as a coated nerve conduit.

In addition, the medical excipients made of chitosan fiber have good biocompatibility and degradability, promote coagulation and inhibit scar hyperplasia, and are the only natural alkaline polysaccharides with excellent broad-spectrum antibacterial properties.

International medical textile material development trend

Special expert of coal general hospital Zhong Xiuling

The medical equipment industry is an important part of the health service industry. It involves a wide range of fields and a long industrial chain. The role of stimulating the economy and absorbing employment is very significant. Since the start of the reform of the medical and health system, the central government has invested more than 160 billion yuan to strengthen the construction of the health and family planning service system. The demand for medical equipment and the market are expanding. Domestic medical equipment enterprises must seize the historical opportunity and become a bigger and stronger enterprise. Promote the rapid development of the health service industry.

Cotton cloth has been used as an in-process protective material, but the use of ordinary cotton cloth has hidden dangers. Cotton wool, dust, bacterial contamination, etc. can cause infections among patients and even doctors and nurses. For example, in an ophthalmic excimer laser surgery in a hospital in Guangdong, diffuse interstitial keratitis (4.1%, 8/195) occurred in 12 eyes of 8 people. The result of the investigation was that the material was aseptically grown, and the air was free of pathogenic bacteria. The number of particles in the operating area exceeded the standard. Reports of postoperative complications of particulate contaminants date back to the 1940s, including: abdominal pain, adhesions, granuloma, osteolysis around the implanted joint, loosening of the implanted tissue, and even failure.

Long-fiber polyester fiber has the characteristics of continuous flocculation, no dust removal, dust and bacteria, static dissipative, anti-pollution, and chemical resistance.

The long-fiber polyester fiber three-layer composite material produced by the invention can realize two-way protection, and the functional surgical drape can be made waterproof, partially absorbent, bacteria-resistant, breathable, anti-static and flame-retardant. In addition, it is made of SMS material non-woven cloth, which has good microbial barrier ability, good impermeability, good firmness and good sag. It is suitable for steam, ethylene oxide, plasma and other sterilization methods. package.

Introduction to chitosan and clinical applications

Wu Juncheng, Director of Burn Cosmetics Center, Taian Central Hospital

The ideal dressing should have: absorb excess wound exudate, creating a moist environment for wound healing

It has good permeability, allows gas exchange, blocks particulate foreign matter in the external environment, including bacteria and other microorganisms, and can maintain the temperature of the wound surface, shielding the wound odor, no residue when replacing, no re-mechanical damage, easy to use, Comfortable, and adapt to all parts of the body, does not affect the body function, high economic characteristics. Chitosan (chitosan), also known as chitosan, is obtained by deacetylation of chitin, which is widely found in nature. The chemical name is polyglucosamine (1-4)-2-amino-BD glucose. . Chitosan dressing is a high-tech wound dressing prepared from chitosan fiber extracted from shrimp, crab, shell, etc., which not only has natural bacteriostasis, hemostasis, promotes wound healing, but also has a good biological phase. Capacitive, biodegradable and biological functions.

The clinical application shows that the appearance is soft and has strong hydrophilicity; it can quickly absorb the effluent on the surface of the wound to form a soft hydrogel, which locks the water for a long time and provides a good moist environment for the wound; The liquid is quickly expanded after being absorbed, and can absorb up to 30 times of its own weight. The infiltrate is retained in situ, no outflow, "locking water" function, transparent, easy to observe; promote wound healing, reduce scar production and contraction, Do not stick when removing the dressing, reducing patient suffering. Suitable for

Wounds with more fluid discharge, such as post-operative wounds, ulcerative wounds, hemorrhoids, granulation and chronic epithelial formation of chronic wounds. In addition, chitosan filled strips and cotton ball-like materials are suitable for hemostasis and healing materials of various lacunar wounds or cave wounds, such as postoperative nasal surgery, sinus, and extraction.